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Comparison of Radiographic and Clinical Status and Peri-implant Crevicular Fluid Prostaglandin E2 Levels Among Patients with Peri-implant Mucositis and Peri-implantitis

Dena Ali, DDS, CAGD, MA, ABGD/Jagan Kumar Baskaradoss, BDS, MPH/Fernanda Oliveira Bello-Correa, DDS, PhD/Adel Al-Asfour, BDS, BA

DOI: 10.11607/prd.6404

The aim was to compare radiographic and clinical status and peri-implant sulcular fluid (PISF) prostaglandin E2 (PGE2) levels among patients with and without peri-implant diseases. Patients with peri-implant mucositis (PiM) (Group-1) and peri-implantitis (Group-2) and individuals without peri-implant diseases (Group-3) were included. Demographic information was collected and peri-implant modified plaque and bleeding indices (mPI and mBI), probing depth (PD) and crestal bone loss (CBL) were recorded. PISF samples were collected and PGE2 levels were measured. Statistical significance was set at P-values that were <0.01. Twenty-two patients with PiM, 22 with peri-implantitis and 23 without peri-implant diseases (controls) were included. Scores of mPI (P<0.01), mBI (P<0.01), and PD (P<0.01) were high among patients with PiM and peri-implantitis than controls. The volumes of collected PISF were significantly high in patients with peri-implantitis (P<0.01) compared to patients with PiM and controls. The PISF volume was significantly high in PiM patients (P<0.01) than controls. There was a significant correlation between peri-implant PD and PISF PGE2 levels in patients with peri-implantitis (P<0.001). Raised PISF PGE2 levels are indicative of poorer peri-implant health. Therefore, PGE2 is a potential biomarker for the assessment of peri-implant health status. Int J Periodontics Restorative Dent. doi: 10.11607/prd.6404

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